Cell Culture Derived AgMNPV Bioinsecticide: Biological Constraints and Bioprocess Issues
نویسندگان
چکیده
منابع مشابه
HEK293 cell culture media study: increasing cell density for different bioprocess applications
Background The increasing demand for biopharmaceuticals produced in mammalian cells has lead industries to enhance bioprocess volumetric productivity through different strategies. Among them, media development is of major interest [1]. According to the increasing constraints regarding the use of animal derived components on industrial bioprocesses but also the drawbacks of its depletion from ce...
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Multivariate analysis of cell culture bioprocess data has the potential of unveiling hidden process characteristics and providing new insights into factors affecting process performance. This study investigated the time-series data of 134 process parameters acquired throughout the inoculum train and the production bioreactors of 243 runs at the Genentech's Vacaville manufacturing facility. Two ...
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Background The use of human embryonic kidney cells (HEK293) for recombinant protein or virus production has gained relevance along the last years. They are specially recommended for transient gene expression and adenovirus or adeno-associated virus generation [1,2]. To achieve high volumetric productivities towards bioprocess optimization, the concentration of biocatalizer (i.e. animal cells) m...
متن کاملAnimal‐cell culture media: History, characteristics, and current issues
Background Cell culture technology has spread prolifically within a century, a variety of culture media has been designed. This review goes through the history, characteristics and current issues of animal-cell culture media. Methods A literature search was performed on PubMed and Google Scholar between 1880 and May 2016 using appropriate keywords. Results At the dawn of cell culture techno...
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Heparin is the most widely used anticoagulant drug in the world today. Heparin is currently produced from animal tissues, primarily porcine intestines. A recent contamination crisis motivated development of a non-animal-derived source of this critical drug. We hypothesized that Chinese hamster ovary (CHO) cells could be metabolically engineered to produce a bioengineered heparin, equivalent to ...
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ژورنال
عنوان ژورنال: Cytotechnology
سال: 2005
ISSN: 0920-9069,1573-0778
DOI: 10.1007/s10616-005-3175-7